Work Package 02: Immunological mechanisms of aseptic loosening
- Work Package Lead
University of Magdeburg
- Partners Involved
University of Tartu
The main objective of Work Package 02 is the investigation of immunological mechanisms of aseptic loosening of orthopaedic endoprostheses. In our previous work we showed the appearance of diffuse and perivascular infiltrates of T- and B- lymphocytes and plasma cells, massive fibrin exudation, accumulation of macrophages. But the mechanisms leading to these signs of adverse immune reaction are not yet understood.