Overall Objectives of HypOrth

The aims of HypOrth in brief are the following:

 

  • Identification of adverse immune reactions (AIR) to implant material and differentiation of AIR from low-grade infection in the context of prosthesis loosening; inclusion of epidemiological and clinical expertise and the finding of diagnostic biomarkers for AIR
  • Understanding of mechanisms of adverse immune reaction and develop predictive computational models
  • Finding of predictive biomarkers for application in personalised medicine
  • Testing of conventional and new material combinations for implant and coating on different cell systems: bone cells and immune cells for biocompatibility, antibacterial properties and evoking immunological parameters including the newly identified biomarkers
  • Evaluation of data, production of prototypic hypoallergenic implant

 

Please visit the section Work Plan for an overview of  the HypOrth Work Packages and the description of their objectives and  tasks.

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